SR9011 SARM Review: Dosage, Benefits, Side Effects and More

SR9011 is what’s known as a Selective Androgen Receptor Modulator, or SARM.

This particular SARM has managed to garnish some considerable interest in the medical research field for its potential to modulate androgen receptors selectively.

It is considered a research chemical, and is typically explored for the reported effects on boosting physical endurance, improving muscle strength, and elevating metabolic function.

In this article, we’ll take a look at the entire scientific landscape surrounding SR9011, including its mechanism of action, how it works, how it compares to similar SARMS, and more.

Let’s dive into the history of SR9011, and SARMS in general.

Background on SARMs & SR9011

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SARMs are a special class of compounds that selectively target and subsequently bring to androgen receptors in the human body.1

They are compounds designed to provide the benefits of androgen activation in specific tissues, like muscle, without the unpleasant and potentially dangerous outcomes that are typically seen when using anabolic steroids, like virilization and negative impacts on cardiovascular health.2

By creating a compound that helps isolate these effects primarily to muscle and bone, SARMs offer incredible therapeutic potential for a long list of conditions that span things like muscle wasting conditions, loss of bone density or mineralization, and even as an adjunct therapy for cachexia in cancer patients.3 

SARMs typically operate by mimicking the effects of a natural hormone, such as testosterone, which is critical for countless bodily processes that include maintaining bone health, growing and adding lean muscle tissue, and promoting secondary sexual characteristics.4

Much of the appeal for many SARMs lies in their uncanny ability to stimulate androgen receptors in muscle as well as bone, with high affinity and specificity, leading to increased anabolic processes.

This increase in anabolic processes occurs with the minimization of potential androgenic effects on secondary organs and systems, like the prostate and the liver.

Although SR9011 is generally classified as a SARM, it’s technically a compound called a Rev-Erbα agonist, which targets very different mechanisms within the body.5

Rev-Erbα is an important protein that is typically involved in regulating our circadian rhythms, as well as the metabolism of lipids and glucose, and finally, inflammatory responses. 

Influencing this protein gives SR9011 the potential to improve the user’s capacity for exercise, metabolic function, and energy expenditure, all of which are priceless for patients who are living with various metabolic syndromes or conditions that lead to muscle and bone degeneration or loss. 

The discovery and development of SR9011 comes from the initial need for compounds that can help enhance the requirements of both metabolic as well as physical parameters, without the often disastrous side effects associated with conventional hormone therapies. 

Initial clinical observations with SR9011 seem to indicate that it can significantly increase athletic endurance and lower anxiety rates, and while these studies focused on animal models, the results show indications of tremendous therapeutic potential.

The ability of SR9011 to help modulate the circadian rhythm also gives it the potential to treat various sleep disorders and metabolic diseases that show clear diurnal variations. 

While this SARM shows tremendous promise, the journey of SR9011 and compounds like it from the lab to the clinic is loaded with challenges.

The safety and ultimate efficacy of these chemicals need to be rigorously challenged and validated to determine their overall therapeutic potential and any long-term impacts or effects that may need to be considered in conjunction with their use.

In general, the interest in SR9011 and other SARMs continues to grow as research digs deeper into the capabilities and potential applications of medicine, fitness, and beyond.

SR9011’s Chemical Properties and Mechanism of Action

SR9011 is distinguished by its unique mechanism of action, which is what makes it different from most other SARMs.

Chemically known as a synthetic Rev-Erbα agonist, SR9011 has been formulated specifically to modulate the activity of that protein, which plays a central role in homeostasis maintenance, regulating energy levels, maintaining lipid and glucose metabolism, and even inflammatory responses in the body.

Rev-Erbα is an integral component of the biological machinery responsible for the expression of core clock proteins and genes involved in metabolic processes.

SR9011 binds to this receptor and activates it, leading to substantial alterations in the body’s metabolic and circadian regulatory works, including the suppression of genes involved in the storage of lipids and the management of glucose levels. 

These, in turn, lead to boosted metabolic rates, lower fat storage rates, and enhanced insulin sensitivity. 

On a molecular level, SR9011 influences the body’s biological clock, resetting and modulating the circadian rhythms, which not only impacts sleep patterns and physical performance but has much broader implications on overall metabolic health.

This may not sound like much, but to put it in perspective, having the proper circadian synchronization can lead to muscle hypertrophy and rapid repair, enhanced energy utilization, and improved recovery processes. 

The improvements in circadian genes triggered by SR9011 can therefore create a substantial strategic advantage in situations where dysregulation of these rhythms is a contributing factor, like in shift work, sleep disorders, and specific metabolic disorders. 

Additionally, SR9011 can enhance endurance during physical exertion by raising the running capacity of skeletal muscles, mediated through an increase in the number of mitochondria in the muscle tissues.

This creates a greater proportion of oxidative fibers, which boosts endurance and raises the oxidative capacity of the muscle, allowing it to use energy more efficiently.

Benefits of SR9011

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Muscle Growth and Endurance Enhancement

One of the most notable, and desirable benefits of SR9011 is the compound’s capacity to boost muscle growth and endurance.

This is most valuable for athletes and others who strive to improve physical performance and body composition since SR9011 raises the oxidative capacity of the muscle, or its raw capacity to do work.

This allows muscles to work more efficiently during periods of prolonged activity, as well as recover from vigorous activity faster, with the compound’s ability to reduce inflammation crucial to speeding healing times. 

Fat Loss and Improved Metabolic Rates

SR9011’s impact on fat loss and metabolic rates is firmly rooted in the compound’s interaction with the circadian machinery and metabolic pathways.

The modulation of Rev-Erbα by SR9011 not only resets the body’s internal clock mechanisms but also decreases the creation of new fat cells while simultaneously promoting the breakdown of stored fat.

This process, known as lipolysis, is elevated specifically during periods where energy demand spikes, like during exercise or fasting states.

Since SR9011 boosts the metabolic rate, the body leverages fat as the primary energy source far more often, which results in lower rates of adiposity and elevated lean muscle mass composition. 

As a result, there is visible fat loss while cardiovascular health is improved from the decrease in lipid profile, leading to a lower risk of fatty liver disease, a common metabolic condition.

Effects on Circadian Rhythms

As we’ve discussed, SR9011’s effects on circadian rhythms are nothing short of profound, which could lead to much more substantial health benefits beyond the currently-known muscle and metabolic improvements.

The unique mechanism of action via protein modulation means SR9011 can effectively reset the body’s internal clock, leading to specific benefits for individuals who experience circadian disruption as a result of shift work, travel, or irregular lifestyle.

Research and Clinical Studies

As we mentioned earlier, most of the preclinical research for SR9011 has been based on animal models, but in these models, SR9011 has demonstrated significant effects on increasing exercise endurance.6

Some research shows that subjects treated with SR9011 could run much for much longer and cover far more distance.7

Other critical research shows SR9011’s impact on the metabolic systems, with findings suggesting that it can mimic some of the effects of caloric restriction without the need to alter food intake.8 9

Studies indicate that SR9011 can reset the body’s internal clock, potentially providing therapeutic benefits for shift workers or individuals suffering from jet lag or sleep conditions.

SR9011 Compared to Other SARMs

Individuals considering SR9011 have no doubt researched other SARMs as well, even if only to a very basic level, but while all SARMs have a similar result, they tend to be far more distinct in their mechanism and scope of action.

This means getting a clear picture of how SR9011 differs from traditional SARMs in this respect can help sharpen the focus on its applications and advantages over other similar compounds in this category.

Traditional SARMs, like Ostarine, Ligandrol, and Andarine are usually known for their selective action on androgen receptors associated with bone and muscle tissues.

They try to mimic the same bone-strengthening and muscle-building effects of testosterone, while simultaneously minimizing the unwanted androgenic effects on the liver, skin, and even prostate. 

This high degree of selectivity makes SARMs hugely popular in clinical settings dealing with conditions like muscle wasting and osteoporosis, as well as in the fitness and bodybuilding space where enthusiasts are always chasing muscle gain and fat loss without anabolic steroid side effects. 

In contrast, SR9011 doesn’t act directly on androgen receptors but instead acts on the Rev-Erbα protein, which impacts the bodily processes governed by the circadian rhythm, such as metabolism, energy expenditure, and even fat storage. 

While SARMs in the traditional sense are potent agents for boosting muscle mass and bone density, SR9011 excels in improving metabolic function and physical endurance, making it uniquely useful for enhancing exercise capacity and battling metabolic disorders. 

Additionally, the ability of SR9011 to assist in circadian rhythm modulation creates additional possibilities for treating sleep disorders and other health issues related to circadian misalignment that are not generally targets for treatment with traditional SARMs.

This aspect of SR9011 could be revolutionary in the medical field for creating new therapeutic avenues for treating circadian disorders, including some psychiatric disorders, obesity, and even diabetes. 

Finally, the differences in safety profiles between SR9011 and other SARMs are significant enough to merit consideration on their own. 

Most SARMs have been extensively studied and are well-understood in their interactions with the human body, SR9011 is newer, and as such, the long-term effects are less understood.

Ongoing research will be needed to fully and firmly establish the safety, efficacy, and potential side effects of SR9011 compared to other, more well-established SARMs.

Final Thoughts

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SR9011 has emerged as a distinctive and promising research chemical that operates in the wider category of performance enhancers and metabolic regulation agents.

Unlike most traditional SARMs which generally focus on muscle and bone androgen receptors, the unique mechanism of action used by SR9011 gives a multifaceted approach to health and fitness by regulating circadian rhythms, modulating metabolic processes, and increasing physical endurance. 

The potential of SR9011 to revolutionize treatment option availability for those struggling with metabolic diseases, sleep disorders, or generally lower physical performance makes it one of the most significant developments in the SARM space. 

That said, much of the research on SR9011 is still in its infancy, and with clinical applications still in their early stages, much is yet to be understood about the long-term impacts and optimal use of SR9011 in the context of human health. 

Ongoing research and continued clinical trials will be foundational to determining the full potential of the compound, and ensuring it can be safely integrated into treatment plans or leveraged in the fitness space.

If you’re considering using SR9011, whether for clinical use or personal health regimens, it’s critical to be informed about the latest research developments and usage guidelines, so that you can have a holistic, balanced view of the benefits and potential risks.

As science advances, SR9011 may prove to be a key component to enhancing physical as well as metabolic health, ultimately improving the overall quality of life for many.

References

1. Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care. 2009 May;12(3):232-40. doi: 10.1097/MCO.0b013e32832a3d79. PMID: 19357508; PMCID: PMC2907129.
2. Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW. Selective androgen receptor modulators: the future of androgen therapy? Transl Androl Urol. 2020 Mar;9(Suppl 2):S135-S148. doi: 10.21037/tau.2019.11.02. PMID: 32257854; PMCID: PMC7108998.
3. Vignali JD, Pak KC, Beverley HR, DeLuca JP, Downs JW, Kress AT, Sadowski BW, Selig DJ. Systematic Review of Safety of Selective Androgen Receptor Modulators in Healthy Adults: Implications for Recreational Users. J Xenobiot. 2023 May 10;13(2):218-236. doi: 10.3390/jox13020017. PMID: 37218811; PMCID: PMC10204391.
4. Bhasin S, Calof OM, Storer TW, Lee ML, Mazer NA, Jasuja R, Montori VM, Gao W, Dalton JT. Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. Nat Clin Pract Endocrinol Metab. 2006 Mar;2(3):146-59. doi: 10.1038/ncpendmet0120. PMID: 16932274; PMCID: PMC2072878.
5. Wolff SEC, Wang XL, Jiao H, Sun J, Kalsbeek A, Yi CX, Gao Y. The Effect of Rev-erbα Agonist SR9011 on the Immune Response and Cell Metabolism of Microglia. Front Immunol. 2020 Sep 25;11:550145. doi: 10.3389/fimmu.2020.550145. PMID: 33101272; PMCID: PMC7546349.
6. Fan W, Atkins AR, Yu RT, Downes M, Evans RM. Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J Mol Endocrinol. 2013 Nov 26;51(3):T87-T100. doi: 10.1530/JME-13-0258. Erratum in: J Mol Endocrinol. 2014 Feb;52(1):X1. PMID: 24280961; PMCID: PMC3936671.
7. Fan W, Evans RM. Exercise Mimetics: Impact on Health and Performance. Cell Metab. 2017 Feb 7;25(2):242-247. doi: 10.1016/j.cmet.2016.10.022. Epub 2016 Nov 23. PMID: 27889389; PMCID: PMC5555683.
8. Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, Shin Y, Liu J, Cameron MD, Noel R, Yoo SH, Takahashi JS, Butler AA, Kamenecka TM, Burris TP. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012 Mar 29;485(7396):62-8. doi: 10.1038/nature11030. PMID: 22460951; PMCID: PMC3343186.
9. Raza GS, Sodum N, Kaya Y, Herzig KH. Role of Circadian Transcription Factor Rev-Erb in Metabolism and Tissue Fibrosis. Int J Mol Sci. 2022 Oct 26;23(21):12954. doi: 10.3390/ijms232112954. PMID: 36361737; PMCID: PMC9655416.
   

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