The Anti Candida Benefits of Oregon Grape Root

By  //  April 21, 2021

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Oregon Grape (Mahonia aquifolium) is an incredible medicinal plant native to the Pacific Northwest (British Columbia, Washington, Oregon, Northern California).

It has potent medicinal compounds and has been used for centuries for its numerous health benefits.

The root of the plant is most commonly used for medicine, as it contains an active compound called berberine. Berberine is defined as a “quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids.”

It is a chemical compound that has many medicinal uses and can be consumed via the consumption of Oregon Grape Root herb, or it can be taken as a concentrated extract. Berberine is most commonly taken for diabetes, high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia), and high blood pressure.

Though Berberine is certainly one of the most important compounds in Oregon Grape Root, it is not the only medicinal compound found in this plant. Oregon Grape Root also contains a variety of alkaloids, including berbamine, berberastine, hydrastine, canadine, corypalmine, meconine, xanthopucine, hydrastidine, and oxyacanthine—each of which offer various medicinal benefits.

Of these active chemical compounds berberine, berbamine and oxyacanthine stand out as being the most medicinal. Berbamine is a bisbenzylisoquinoline alkaloid that has been investigated for its in vitro anti-inflammatory action that appears to hinder the gene expression of inflammatory mediators.

Oxyacanthine is a bitter crystalline alkaloid that has shown strong anti-inflammatory and antioxidant properties. Research shows it is effective for inhibiting lipid peroxidation, a major cause of cell damage.

Oregon Grape Root has been used extensively for a variety of uses, including being used for stomach ulcers, gastroesophageal reflux disease (GERD), stomach upset, as a bitter tonic, to treat infections, and to cleanse the bowels. One of its most notable benefits is that it helps significantly in the treatment of Candida overgrowth (Candidiasis).

Oregon Grape Root for Candida Infection

Candida is a type of yeast, or single-celled fungi, that exists as part of the body’s natural microflora. When Candida populations are normal they are harmless. When they grow out of control, however, they begin to cause various health issues. The compounds in Oregon Grape Root are strongly antifungal, and so they can help tremendously in reducing Candida populations back to their normal levels.

The interesting thing about Oregon Grape Root when compared to other antifungal agents, is that Oregon Grape Root has been shown to work specifically on the Candida albicans strain, the most common type of Candida that leads to infection. Berberine, one of the main compounds in Oregon Grape Root, has been proven to have broad antibacterial and antifungal activity.

In one research paper published in the National Library of Medicine, the potential antifungal effect of berberine against fluconazole-resistant Candida and Cryptococcus neoformans strains was assessed.

The study showed that berberine may reduce the viability of biofilms formed by fluconazole-resistant Candida cells grown in vitro. Therefore, because of its antimicrobial activity, berberine is a promising source of molecules with great antifungal properties.

Consuming Oregon Grape Root for Candida Infection

Research shows that the berberine compound, the primary active compound in Oregon Grape Root, has a very low rate of absorption.

This poses an issue with using berberine for its medicinal use. While it has incredible properties and health benefits, these are of little use if they cannot be absorbed by the body. Because of this, it’s important to find an Oregon Grape Root supplement that has an effective extraction method that helps to optimizes its bioavailability.

Zuma Nutrition’s Candida Cleanse tonic, for example, features Oregon Grape Root as its primary ingredient due to its exceptional antifungal properties, and they use a therapeutic dose extraction method that significantly increases the rate of absorption, as well as the effectiveness of the dosage. Their formula features other anti-Candida herbs that work synergistically to reduce Candida overgrowth.


Oregon Grape is a medicinal plant native to the Pacific Northwest that has potent medicinal compounds and has been used for centuries for its numerous health benefits. The root of the plant is most commonly used for medicine, as it contains numerous active compounds—the most notable of which is berberine, a benzylisoquinoline alkaloids that exhibits many medicinal properties.

Berberine is strongly anti-fungal, so it works great for treating fungal infections, especially those caused by Candida yeasts. When using Oregon Grape Root for its medicinal value, you want to be sure to find a supplement that uses a good extraction method. This will help you get the most out of this herb, as some of its compounds are otherwise hard for the body to absorb.